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Target
Signal peptide peptidase-like 2A
Ligand
BDBM50263004
Substrate
n/a
Meas. Tech.
ChEMBL_1697323 (CHEMBL4048213)
IC50
137±n/a nM
Citation
 Velcicky, J; Bodendorf, U; Rigollier, P; Epple, R; Beisner, DR; Guerini, D; Smith, P; Liu, B; Feifel, R; Wipfli, P; Aichholz, R; Couttet, P; Dix, I; Widmer, T; Wen, B; Brandl, T Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo. J Med Chem 61:865-880 (2018) [PubMed]  Article 
Target
Name:
Signal peptide peptidase-like 2A
Synonyms:
3.4.23.- | IMP-3 | Imp3 | Intramembrane protease 3 | Presenilin-like protein 2 | Psl2 | SPP-like 2A | SPP2A_MOUSE | Signal peptide peptidase-like 2A | Sppl2a | Synonyms=Imp3
Type:
PROTEIN
Mol. Mass.:
58131.12
Organism:
Mus musculus
Description:
ChEMBL_117553
Residue:
523
Sequence:
MGLLHSLHAPAAALLWSCLLGLAAAQEAILHASTNGVSSLSKDYCMYYNNNWTRLPSSLENATSLSLMNLTGTALCHLSDIPPDGIRNKAVVVHWGPCHFLEKARIAQEGGAAALLIANNSVLIPSSRNKSTFQNVTVLIAVITQKDFKDMKETLGDDITVKMYSPSWPNFDYTLVVIFVIAVFTVALGGYWSGLIELENMKSVEDAEDRETRKKKDDYLTFSPLTVVVFVVICCIMIVLLYFFYRWLVYVMIAIFCIASSMSLYNCLSALIHRMPCGQCTILCCGKNIKVSLIFLSGLCISVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTMKLPNFMSCVILLGLLLIYDVFFVFITPFITKNGESIMVELAAGPFENAEKLPVVIRVPKLMGYSVMSVCSVPVSVLGFGDIIVPGLLIAYCRRFDVQTGSSIYYISSTIAYAVGMIITFVVLMVMKTGQPALLYLVPCTLITVSVVAWSRKEMKKFWKGSSYQVMDHLDYSTNEENPVTTDEQIVQQ
  
Inhibitor
Name:
BDBM50263004
Synonyms:
CHEMBL4069936
Type:
Small organic molecule
Emp. Form.:
C27H28FN5O4
Mol. Mass.:
505.5407
SMILES:
Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r|
Structure:
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