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Target
Signal peptide peptidase-like 2B
Ligand
BDBM50263004
Substrate
n/a
Meas. Tech.
ChEBML_1697377
IC50
430±n/a nM
Citation
 Velcicky, J; Bodendorf, U; Rigollier, P; Epple, R; Beisner, DR; Guerini, D; Smith, P; Liu, B; Feifel, R; Wipfli, P; Aichholz, R; Couttet, P; Dix, I; Widmer, T; Wen, B; Brandl, T Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo. J Med Chem 61:865-880 (2018) [PubMed]  Article 
Target
Name:
Signal peptide peptidase-like 2B
Synonyms:
3.4.23.- | IMP-4 | IMP4 | Intramembrane protease 4 | KIAA1532 | PSH4 | PSL1 | Presenilin homologous protein 4 | Presenilin-like protein 1 | SPP-like 2B | SPP2B_HUMAN | SPPL2B | Signal peptide peptidase-like 2B | Synonyms=IMP4
Type:
PROTEIN
Mol. Mass.:
64655.18
Organism:
Homo sapiens
Description:
ChEMBL_117517
Residue:
592
Sequence:
MAAAVAAALARLLAAFLLLAAQVACEYGMVHVVSQAGGPEGKDYCILYNPQWAHLPHDLSKASFLQLRNWTASLLCSAADLPARGFSNQIPLVARGNCTFYEKVRLAQGSGARGLLIVSRERLVPPGGNKTQYDEIGIPVALLSYKDMLDIFTRFGRTVRAALYAPKEPVLDYNMVIIFIMAVGTVAIGGYWAGSRDVKKRYMKHKRDDGPEKQEDEAVDVTPVMTCVFVVMCCSMLVLLYYFYDLLVYVVIGIFCLASATGLYSCLAPCVRRLPFGKCRIPNNSLPYFHKRPQARMLLLALFCVAVSVVWGVFRNEDQWAWVLQDALGIAFCLYMLKTIRLPTFKACTLLLLVLFLYDIFFVFITPFLTKSGSSIMVEVATGPSDSATREKLPMVLKVPRLNSSPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGVGLLVTFVALALMQRGQPALLYLVPCTLVTSCAVALWRRELGVFWTGSGFAKVLPPSPWAPAPADGPQPPKDSATPLSPQPPSEEPATSPWPAEQSPKSRTSEEMGAGAPMREPGSPAESEGRDQAQPSPVTQPGASA
  
Inhibitor
Name:
BDBM50263004
Synonyms:
CHEMBL4069936
Type:
Small organic molecule
Emp. Form.:
C27H28FN5O4
Mol. Mass.:
505.5407
SMILES:
Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r|
Structure:
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