Reaction Details Report a problem with these data
Target
Somatostatin receptor type 2
Ligand
BDBM50451390
Substrate
n/a
Meas. Tech.
ChEMBL_1745056 (CHEMBL4179566)
IC50
0.680000±n/a nM
Citation
 Banno, Y; Sasaki, S; Kamata, M; Kunitomo, J; Miyamoto, Y; Abe, H; Taya, N; Oi, S; Watanabe, M; Urushibara, T; Hazama, M; Niwa, SI; Miyamoto, S; Horinouchi, A; Kuroshima, KI; Amano, N; Matsumoto, SI; Matsunaga, S Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes. Bioorg Med Chem 25:5995-6006 (2017) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS-2-R | SS2-R | SS2R | SSR2_HUMAN | SSTR2 | Somatostatin receptor type 2 (SSTR2)
Type:
Enzyme
Mol. Mass.:
41344.94
Organism:
Homo sapiens (Human)
Description:
P30874
Residue:
369
Sequence:
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Inhibitor
Name:
BDBM50451390
Synonyms:
CHEMBL4210627
Type:
Small organic molecule
Emp. Form.:
C34H39N5O4S
Mol. Mass.:
613.77
SMILES:
C[C@H]([C@@H](NC(=O)N1CCC(CC1)C(=O)c1cccs1)C(=O)Nc1cc(CN(C)C)ccc1C(C)=O)c1c[nH]c2ccccc12 |r|
Structure:
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