Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50478963
Substrate
n/a
Meas. Tech.
ChEMBL_488507 (CHEMBL991040)
IC50
>1000±n/a nM
Citation
 Pace, P; Spieser, SA; Summa, V 4-Hydroxy-5-pyrrolinone-3-carboxamide HIV-1 integrase inhibitors. Bioorg Med Chem Lett 18:3865-9 (2008) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50478963
Synonyms:
CHEMBL480717
Type:
Small organic molecule
Emp. Form.:
C26H28F2N4O5
Mol. Mass.:
514.5211
SMILES:
OC1=C(C(N(CCN2CCOCC2)C1=O)C(=O)NCc1ccc(F)cc1)C(=O)NCc1ccc(F)cc1 |t:1|
Structure:
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