Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50484379
Substrate
n/a
Meas. Tech.
ChEMBL_787739 (CHEMBL1918322)
IC50
1.000000±n/a nM
Citation
 Johns, BA; Kawasuji, T; Weatherhead, JG; Boros, EE; Thompson, JB; Garvey, EP; Foster, SA; Jeffrey, JL; Miller, WH; Kurose, N; Matsumura, K; Fujiwara, T Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors. Bioorg Med Chem Lett 21:6461-4 (2011) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50484379
Synonyms:
CHEMBL1917873
Type:
Small organic molecule
Emp. Form.:
C19H18FN3O3
Mol. Mass.:
355.3629
SMILES:
CC(C)n1c2cccnc2c(O)c(C(=O)NCc2ccc(F)cc2)c1=O
Structure:
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