Reaction Details Report a problem with these data
Target
Presenilin-1
Ligand
BDBM50484472
Substrate
n/a
Meas. Tech.
ChEMBL_787715 (CHEMBL1918257)
IC50
5.5±n/a nM
Citation
Stepan, AF; Karki, K; McDonald, WS; Dorff, PH; Dutra, JK; Dirico, KJ; Won, A; Subramanyam, C; Efremov, IV; O'Donnell, CJ; Nolan, CE; Becker, SL; Pustilnik, LR; Sneed, B; Sun, H; Lu, Y; Robshaw, AE; Riddell, D; O'Sullivan, TJ; Sibley, E; Capetta, S; Atchison, K; Hallgren, AJ; Miller, E; Wood, A; Obach, RS Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as ?-secretase inhibitors. J Med Chem 54:7772-83 (2011) [PubMed] Article
More Info.:
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Human
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI