Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50036257
Substrate
n/a
Meas. Tech.
ChEMBL_157540 (CHEMBL764925)
Ki
0.5±n/a nM
Citation
 Vazquez, ML; Bryant, ML; Clare, M; DeCrescenzo, GA; Doherty, EM; Freskos, JN; Getman, DP; Houseman, KA; Julien, JA; Kocan, GP Inhibitors of HIV-1 protease containing the novel and potent (R)-(hydroxyethyl)sulfonamide isostere. J Med Chem 38:581-4 (1995) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50036257
Synonyms:
((S)-1-{(1S,2R)-3-[Benzenesulfonyl-(3-methyl-butyl)-amino]-1-benzyl-2-hydroxy-propylcarbamoyl}-2-carbamoyl-ethyl)-carbamic acid pyridin-2-ylmethyl ester | CHEMBL351994
Type:
Small organic molecule
Emp. Form.:
C32H41N5O7S
Mol. Mass.:
639.762
SMILES:
CC(C)CCN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccn1)S(=O)(=O)c1ccccc1
Structure:
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