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Target
Type-1 angiotensin II receptor
Ligand
BDBM50009714
Substrate
n/a
Meas. Tech.
ChEMBL_36630 (CHEMBL652869)
IC50
40±n/a nM
Citation
 Ashton, WT; Chang, LL; Flanagan, KL; Hutchins, SM; Naylor, EM; Chakravarty, PK; Patchett, AA; Greenlee, WJ; Chen, TB; Faust, KA Triazolinone biphenylsulfonamide derivatives as orally active angiotensin II antagonists with potent AT1 receptor affinity and enhanced AT2 affinity. J Med Chem 37:2808-24 (1994) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50009714
Synonyms:
CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-3H-imidazol-4-yl}-methanol(DuP 753)
Type:
Small organic molecule
Emp. Form.:
C22H25ClN6O
Mol. Mass.:
424.927
SMILES:
CCCCC1=NC(Cl)C(CO)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 |t:4|
Structure:
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