Affinity DataIC50: 0.100nMAssay Description:Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Displacement of [125I]-Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.110nMAssay Description:In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIMore data for this Ligand-Target Pair
Affinity DataIC50: 0.110nMAssay Description:In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.120nMAssay Description:Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.130nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.130nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.130nMAssay Description:In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIMore data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.160nMAssay Description:In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIMore data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMAssay Description:Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMAssay Description:In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIMore data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMAssay Description:In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIMore data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1More data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.190nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.190nMAssay Description:Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.190nMAssay Description:In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIMore data for this Ligand-Target Pair
Affinity DataIC50: 0.190nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membraneMore data for this Ligand-Target Pair
TargetType-1/Type-2 angiotensin II receptor(Homo sapiens (Human))
Exploratory Chemistry Merck Sharp And Dohme Research Laboratories
Curated by ChEMBL
Exploratory Chemistry Merck Sharp And Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Binding affinity towards Angiotensin receptor from rabbit aortaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:In vitro binding affinity of the compound for angiotensin II AT1 receptor in rabbit aortaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1More data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:In vitro binding affinity of the compound for angiotensin II AT1 receptor in rabbit aortaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIMore data for this Ligand-Target Pair
Affinity DataIC50: 0.230nMAssay Description:In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.230nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1More data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1More data for this Ligand-Target Pair