Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50494143
Substrate
n/a
Meas. Tech.
ChEMBL_1276466 (CHEMBL3088590)
Ki
52±n/a nM
Citation
 Rami, M; Dubois, L; Parvathaneni, NK; Alterio, V; van Kuijk, SJ; Monti, SM; Lambin, P; De Simone, G; Supuran, CT; Winum, JY Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates. J Med Chem 56:8512-20 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50494143
Synonyms:
CHEMBL3087327
Type:
Small organic molecule
Emp. Form.:
C7H14N4O2S
Mol. Mass.:
218.277
SMILES:
Cc1nccn1CCCNS(N)(=O)=O
Structure:
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