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Target
Endothelial lipase
Ligand
BDBM50506735
Substrate
n/a
Meas. Tech.
ChEMBL_1827144 (CHEMBL4327018)
IC50
49±n/a nM
Citation
 Hu, CH; Wang, TC; Qiao, JX; Haque, L; Chen, AYA; Taylor, DS; Ying, X; Onorato, JM; Galella, M; Shen, H; Huang, CS; Toussaint, N; Li, YX; Abell, L; Adam, LP; Gordon, D; Wexler, RR; Finlay, HJ Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors. Bioorg Med Chem Lett 28:3721-3725 (2018) [PubMed]  Article 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Human
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM50506735
Synonyms:
CHEMBL4583457
Type:
Small organic molecule
Emp. Form.:
C22H22N4O4
Mol. Mass.:
406.4345
SMILES:
Nc1c([nH]c(=O)[nH]c1=O)C(=O)N[C@@H]1CCCc2c(OCc3ccccc3)cccc12 |r|
Structure:
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