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Target
RNA-directed RNA polymerase
Ligand
BDBM50507437
Substrate
n/a
Meas. Tech.
ChEMBL_1830025 (CHEMBL4329899)
EC50
8.8±n/a nM
Citation
 Yeung, KS; Beno, BR; Mosure, K; Zhu, J; Grant-Young, KA; Parcella, K; Anjanappa, P; Bora, RO; Selvakumar, K; Wang, YK; Fang, H; Krause, R; Rigat, K; Liu, M; Lemm, J; Sheriff, S; Witmer, M; Tredup, J; Jardel, A; Kish, K; Parker, D; Haskell, R; Santone, K; Meanwell, NA; Soars, MG; Roberts, SB; Kadow, JF Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors. ACS Med Chem Lett 9:1217-1222 (2018) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50507437
Synonyms:
CHEMBL4549638
Type:
Small organic molecule
Emp. Form.:
C33H30FN5O5S
Mol. Mass.:
627.685
SMILES:
CCN(c1cc2oc(c(C(=O)NC)c2cc1-c1cccc(c1)C(=O)NC1(CC1)c1ncccn1)-c1ccc(F)cc1)S(C)(=O)=O
Structure:
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