Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50386790
Substrate
n/a
Meas. Tech.
ChEMBL_1853918 (CHEMBL4354542)
EC50
37±n/a nM
Citation
 Li, Z; Liu, C; Yang, J; Zhou, J; Ye, Z; Feng, D; Yue, N; Tong, J; Huang, W; Qian, H Design, synthesis and biological evaluation of novel FFA1/GPR40 agonists: New breakthrough in an old scaffold. Eur J Med Chem 179:608-622 (2019) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50386790
Synonyms:
CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US11905230, Example TAK-875
Type:
Small organic molecule
Emp. Form.:
C29H32O7S
Mol. Mass.:
524.625
SMILES:
Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 |r|
Structure:
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