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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50523016
Substrate
n/a
Meas. Tech.
ChEMBL_1888841 (CHEMBL4390518)
EC50
44±n/a nM
Citation
 Harada, K; Mizukami, J; Watanabe, T; Mori, G; Ubukata, M; Suwa, K; Fukuda, S; Negoro, T; Sato, M; Inaba, T Optimization of oxadiazole derivatives with a spirocyclic cyclohexane structure as novel GPR119 agonists. Bioorg Med Chem Lett 29:2100-2106 (2019) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50523016
Synonyms:
CHEMBL4441091
Type:
Small organic molecule
Emp. Form.:
C23H31FN2O5S
Mol. Mass.:
466.566
SMILES:
CC(O[C@H]1CC[C@@]2(COC(C)(C)C2)CC1)c1nc(no1)-c1ccc(CS(C)(=O)=O)c(F)c1 |r,wU:6.6,3.2,(48.16,-18.86,;48.18,-20.4,;49.59,-21.02,;50.84,-20.12,;50.68,-18.59,;51.94,-17.69,;53.35,-18.32,;53.27,-16.78,;54.71,-16.22,;55.67,-17.42,;57,-16.64,;57.01,-18.18,;54.84,-18.72,;53.5,-19.86,;52.25,-20.75,;46.94,-21.3,;45.47,-20.83,;44.56,-22.08,;45.47,-23.33,;46.94,-22.85,;43.02,-22.08,;42.25,-20.74,;40.71,-20.75,;39.94,-22.08,;38.41,-22.09,;37.63,-20.75,;36.1,-20.76,;38.02,-19.26,;39.12,-20.35,;40.71,-23.41,;39.94,-24.74,;42.25,-23.41,)|
Structure:
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