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Target
Solute carrier family 2, facilitated glucose transporter member 3
Ligand
BDBM453227
Substrate
n/a
Meas. Tech.
ChEMBL_1972719 (CHEMBL4605537)
IC50
68±n/a nM
Citation
 Liu, KG; Kim, JI; Olszewski, K; Barsotti, AM; Morris, K; Lamarque, C; Yu, X; Gaffney, J; Feng, XJ; Patel, JP; Poyurovsky, MV Discovery and Optimization of Glucose Uptake Inhibitors. J Med Chem 63:5201-5211 (2020) [PubMed]  Article 
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 3
Synonyms:
GLUT-3 | GLUT3 | GTR3_HUMAN | Glucose transporter type 3, brain | SLC2A3 | Solute carrier family 2, facilitated glucose transporter member 3
Type:
PROTEIN
Mol. Mass.:
53925.15
Organism:
Human
Description:
ChEMBL_101113
Residue:
496
Sequence:
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAKETTTNV
  
Inhibitor
Name:
BDBM453227
Synonyms:
US10729691, Example 12
Type:
Small organic molecule
Emp. Form.:
C27H26N6O3
Mol. Mass.:
482.5337
SMILES:
O=C(COc1cccc(c1)-c1nc2COCc2c(Nc2ccc(cc2)-c2cn[nH]c2)n1)NC1CCC1
Structure:
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