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Target
Histamine H4 receptor
Ligand
BDBM22914
Substrate
n/a
Meas. Tech.
ChEMBL_1973792 (CHEMBL4606610)
Ki
79±n/a nM
Citation
 Bartole, E; Grätz, L; Littmann, T; Wifling, D; Seibel, U; Buschauer, A; Bernhardt, G UR-DEBa242: A Py-5-Labeled Fluorescent Multipurpose Probe for Investigations on the Histamine H J Med Chem 63:5297-5311 (2020) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
HH4R | HRH4_MOUSE | Hrh4
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44272.75
Organism:
Mouse
Description:
Cell pellets from SK-N-MC cells transfected with mouse H4 receptor were used in binding assay.
Residue:
391
Sequence:
MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS
  
Inhibitor
Name:
BDBM22914
Synonyms:
CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide | Thioperamide | US11622967, Compound Thioperamide
Type:
Small organic molecule
Emp. Form.:
C15H24N4S
Mol. Mass.:
292.443
SMILES:
S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Structure:
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