Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50540817
Substrate
n/a
Meas. Tech.
ChEMBL_1983060 (CHEMBL4616322)
Ki
71±n/a nM
Citation
 Franchini, S; Linciano, P; Puja, G; Tait, A; Borsari, C; Denora, N; Iacobazzi, RM; Brasili, L; Sorbi, C Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents. ACS Med Chem Lett 11:1028-1034 (2020) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50540817
Synonyms:
CHEMBL4632842
Type:
Small organic molecule
Emp. Form.:
C26H31NO4S2
Mol. Mass.:
485.659
SMILES:
OC(=O)C(O)=O.C([C@@H]1CS[C@]2(CCc3ccccc23)S1)N1CCC(Cc2ccccc2)CC1 |r|
Structure:
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