Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50540833
Substrate
n/a
Meas. Tech.
ChEMBL_1983062 (CHEMBL4616324)
Ki
12±n/a nM
Citation
 Franchini, S; Linciano, P; Puja, G; Tait, A; Borsari, C; Denora, N; Iacobazzi, RM; Brasili, L; Sorbi, C Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents. ACS Med Chem Lett 11:1028-1034 (2020) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50540833
Synonyms:
CHEMBL4645500
Type:
Small organic molecule
Emp. Form.:
C23H33NO4S2
Mol. Mass.:
451.642
SMILES:
OC(=O)C(O)=O.C(C1CSC2(CCCCC2)S1)N1CCC(Cc2ccccc2)CC1
Structure:
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