Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50545888
Substrate
n/a
Meas. Tech.
ChEMBL_2013168 (CHEMBL4666746)
EC50
>10000±n/a nM
Citation
 Shinozuka, T; Tsukada, T; Fujii, K; Tokumaru, E; Matsui, Y; Wakimoto, S; Ogata, T; Araki, K; Sawamura, R; Watanabe, N; Mori, M; Tanaka, J Structure-Activity Relationship Studies of 3- or 4-Pyridine Derivatives of DS-6930. ACS Med Chem Lett 10:358-362 (2019) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50545888
Synonyms:
CHEMBL4749151
Type:
Small organic molecule
Emp. Form.:
C24H23N3O4
Mol. Mass.:
417.4571
SMILES:
Cc1ccc(Oc2cc(C)c3nc(COc4cccc(c4)C(O)=O)n(C)c3c2)c(C)n1
Structure:
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