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Target
Insulin-like growth factor-binding protein 3
Ligand
BDBM50106443
Substrate
n/a
Meas. Tech.
ChEMBL_90405 (CHEMBL698360)
Ki
7.5±n/a nM
Citation
 Chen, C; Zhu, YF; Liu, XJ; Lu, ZX; Xie, Q; Ling, N Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. J Med Chem 44:4001-10 (2001) [PubMed]  Article 
Target
Name:
Insulin-like growth factor-binding protein 3
Synonyms:
IBP3 | IBP3_HUMAN | IGFBP3 | Insulin-like growth factor binding protein 3
Type:
PROTEIN
Mol. Mass.:
31690.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_90404
Residue:
291
Sequence:
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
  
Inhibitor
Name:
BDBM50106443
Synonyms:
1-(3,4-Dihydroxy-benzyl)-6,7-dihydroxy-isoquinoline-3-carboxylic acid | CHEMBL58396
Type:
Small organic molecule
Emp. Form.:
C17H13NO6
Mol. Mass.:
327.2882
SMILES:
OC(=O)c1cc2cc(O)c(O)cc2c(Cc2ccc(O)c(O)c2)n1
Structure:
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