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Target
Glutamate carboxypeptidase 2
Ligand
BDBM50116251
Substrate
n/a
Meas. Tech.
ChEBML_70193
IC50
3±n/a nM
Citation
 Tsukamoto, T; Flanary, JM; Rojas, C; Slusher, BS; Valiaeva, N; Coward, JK Phosphonate and phosphinate analogues of N-acylated gamma-glutamylglutamate. potent inhibitors of glutamate carboxypeptidase II. Bioorg Med Chem Lett 12:2189-92 (2002) [PubMed]  Article 
Target
Name:
Glutamate carboxypeptidase 2
Synonyms:
FOLH1_RAT | Folh1 | Glutamate carboxypeptidase II | Naalad1
Type:
PROTEIN
Mol. Mass.:
84547.28
Organism:
Rattus norvegicus
Description:
ChEMBL_68365
Residue:
752
Sequence:
MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMKKAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLSYPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPGVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIGYDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNVIGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLTKELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNPILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNKVDTSKAWREVKRQISIAAFTVQAAAETLREVD
  
Inhibitor
Name:
BDBM50116251
Synonyms:
2-{[3-(4-Amino-benzoylamino)-3-carboxy-propyl]-hydroxy-phosphinoyloxy}-pentanedioic acid | CHEMBL307085
Type:
Small organic molecule
Emp. Form.:
C16H21N2O10P
Mol. Mass.:
432.3191
SMILES:
Nc1ccc(cc1)C(=O)N[C@@H](CCP(O)(=O)O[C@@H](CCC(O)=O)C(O)=O)C(O)=O
Structure:
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