Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 3
Ligand
BDBM50117443
Substrate
n/a
Meas. Tech.
ChEMBL_49848 (CHEMBL660813)
IC50
237±n/a nM
Citation
 De Lucca, GV; Kim, UT; Johnson, C; Vargo, BJ; Welch, PK; Covington, M; Davies, P; Solomon, KA; Newton, RC; Trainor, GL; Decicco, CP; Ko, SS Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists. J Med Chem 45:3794-804 (2002) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
  
Inhibitor
Name:
BDBM50117443
Synonyms:
1-[6-(4-Benzyl-piperidin-1-ylmethyl)-benzo[1,3]dioxol-5-yl]-3-(3-cyano-phenyl)-urea | CHEMBL123962
Type:
Small organic molecule
Emp. Form.:
C28H28N4O3
Mol. Mass.:
468.5469
SMILES:
O=C(Nc1cccc(c1)C#N)Nc1cc2OCOc2cc1CN1CCC(Cc2ccccc2)CC1
Structure:
Search PDB for entries with ligand similarity: