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Target
Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM50125498
Substrate
n/a
Meas. Tech.
ChEMBL_214949 (CHEMBL819400)
IC50
18±n/a nM
Citation
 Miao, S; Bao, J; Garcia, ML; Goulet, JL; Hong, XJ; Kaczorowski, GJ; Kayser, F; Koo, GC; Kotliar, A; Schmalhofer, WA; Shah, K; Sinclair, PJ; Slaughter, RS; Springer, MS; Staruch, MJ; Tsou, NN; Wong, F; Parsons, WH; Rupprecht, KM Benzamide derivatives as blockers of Kv1.3 ion channel. Bioorg Med Chem Lett 13:1161-4 (2003) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
63835.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513935
Residue:
575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
  
Inhibitor
Name:
BDBM50125498
Synonyms:
Allyl-carbamic acid 4-[(2-methoxy-benzoylamino)-methyl]-4-phenyl-cyclohexyl ester | CHEMBL278660
Type:
Small organic molecule
Emp. Form.:
C25H30N2O4
Mol. Mass.:
422.5167
SMILES:
COc1ccccc1C(=O)NC[C@]1(CC[C@@H](CC1)OC(=O)NCC=C)c1ccccc1 |wU:12.12,wD:15.19,(3.96,3.63,;5.29,2.86,;5.29,1.32,;6.63,.55,;6.63,-1.01,;5.29,-1.78,;3.96,-1.01,;3.96,.55,;2.62,1.32,;2.62,2.86,;1.29,.55,;-.05,1.32,;-1.38,.55,;-.05,-.22,;-.05,-1.78,;-1.38,-2.55,;-2.7,-1.78,;-2.7,-.22,;-1.39,-4.09,;-2.73,-4.83,;-2.75,-6.37,;-4.06,-4.04,;-5.41,-4.81,;-6.73,-4.02,;-8.08,-4.79,;-2.72,1.32,;-4.06,.55,;-5.39,1.32,;-5.39,2.86,;-4.05,3.63,;-2.72,2.86,)|
Structure:
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