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Target
RNA-directed RNA polymerase
Ligand
BDBM50126679
Substrate
n/a
Meas. Tech.
ChEMBL_163994 (CHEMBL766521)
IC50
700±n/a nM
Citation
Chan, L; Reddy, TJ; Proulx, M; Das, SK; Pereira, O; Wang, W; Siddiqui, A; Yannopoulos, CG; Poisson, C; Turcotte, N; Drouin, A; Alaoui-Ismaili, MH; Bethell, R; Hamel, M; L'Heureux, L; Bilimoria, D; Nguyen-Ba, N Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase. J Med Chem 46:1283-5 (2003) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50126679
Synonyms:
(S)-2-(2,4-dichloro-N-(3-nitrobenzyl)benzamido)-3-phenylpropanoic acid | 2-[(2,4-Dichloro-benzoyl)-(3-nitro-benzyl)-amino]-3-phenyl-propionic acid | CHEMBL23458
Type:
Small organic molecule
Emp. Form.:
C23H18Cl2N2O5
Mol. Mass.:
473.305
SMILES:
OC(=O)[C@H](Cc1ccccc1)N(Cc1cccc(c1)[N+]([O-])=O)C(=O)c1ccc(Cl)cc1Cl |r|