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Target
RNA-directed RNA polymerase
Ligand
BDBM50126680
Substrate
n/a
Meas. Tech.
ChEMBL_163994 (CHEMBL766521)
IC50
6000±n/a nM
Citation
 Chan, L; Reddy, TJ; Proulx, M; Das, SK; Pereira, O; Wang, W; Siddiqui, A; Yannopoulos, CG; Poisson, C; Turcotte, N; Drouin, A; Alaoui-Ismaili, MH; Bethell, R; Hamel, M; L'Heureux, L; Bilimoria, D; Nguyen-Ba, N Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase. J Med Chem 46:1283-5 (2003) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50126680
Synonyms:
(S)-2-(2,4-dichloro-N-(2-cyanobenzyl)benzamido)-3-phenylpropanoic acid | 2-[(2-Cyano-benzyl)-(2,4-dichloro-benzoyl)-amino]-3-phenyl-propionic acid | CHEMBL280861
Type:
Small organic molecule
Emp. Form.:
C24H18Cl2N2O3
Mol. Mass.:
453.317
SMILES:
OC(=O)[C@H](Cc1ccccc1)N(Cc1ccccc1C#N)C(=O)c1ccc(Cl)cc1Cl |r|
Structure:
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