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Target
Serine/threonine-protein kinase D2
Ligand
BDBM50565692
Substrate
n/a
Meas. Tech.
ChEMBL_2093047 (CHEMBL4774310)
IC50
43±n/a nM
Citation
 Gilles, P; Kashyap, RS; Freitas, MJ; Ceusters, S; Van Asch, K; Janssens, A; De Jonghe, S; Persoons, L; Cobbaut, M; Daelemans, D; Van Lint, J; Voet, ARD; De Borggraeve, WM Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors. Eur J Med Chem 205:0 (2020) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase D2
Synonyms:
KPCD2_HUMAN | PKD2 | PRKD2
Type:
Protein
Mol. Mass.:
96755.22
Organism:
Homo sapiens (Human)
Description:
Q9BZL6
Residue:
878
Sequence:
MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL
  
Inhibitor
Name:
BDBM50565692
Synonyms:
CHEMBL4790321
Type:
Small organic molecule
Emp. Form.:
C18H20N6O
Mol. Mass.:
336.391
SMILES:
CC(C)(CO)Cn1nc(-c2c[nH]c3ccccc23)c2c(N)ncnc12
Structure:
Search PDB for entries with ligand similarity: