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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50107542
Substrate
n/a
Meas. Tech.
ChEMBL_153392 (CHEMBL763845)
EC50
1300±n/a nM
Citation
 Nomura, M; Tanase, T; Ide, T; Tsunoda, M; Suzuki, M; Uchiki, H; Murakami, K; Miyachi, H Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor alpha subtype-selective activators. J Med Chem 46:3581-99 (2003) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50107542
Synonyms:
3-[4-Methoxy-3-(4-trifluoromethyl-benzylcarbamoyl)-phenyl]-propionic acid | CHEMBL118413
Type:
Small organic molecule
Emp. Form.:
C19H18F3NO4
Mol. Mass.:
381.3457
SMILES:
COc1ccc(CCC(O)=O)cc1C(=O)NCc1ccc(cc1)C(F)(F)F
Structure:
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