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Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM50574921
Substrate
n/a
Meas. Tech.
ChEMBL_2123711 (CHEMBL4832944)
IC50
2.0±n/a nM
Citation
 Miah, AH; Smith, IED; Rackham, M; Mares, A; Thawani, AR; Nagilla, R; Haile, PA; Votta, BJ; Gordon, LJ; Watt, G; Denyer, J; Fisher, DT; Dace, P; Giffen, P; Goncalves, A; Churcher, I; Scott-Stevens, P; Harling, JD Optimization of a Series of RIPK2 PROTACs. J Med Chem 64:12978-13003 (2021) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
  
Inhibitor
Name:
BDBM50574921
Synonyms:
CHEMBL4856422
Type:
Small organic molecule
Emp. Form.:
C54H74N8O11S2
Mol. Mass.:
1075.342
SMILES:
CC[C@@H](NC(=O)[C@@H]1C[C@@H](CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)NC(=O)COCCOCCOCCOCCOc1cc2nccc(Nc3ccc4scnc4c3)c2cc1S(=O)(=O)C(C)(C)C)c1ccccc1 |r|
Structure:
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