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Target
DNA excision repair protein ERCC-5
Ligand
BDBM50157845
Substrate
n/a
Meas. Tech.
ChEMBL_305129 (CHEMBL832425)
IC50
0.327±n/a nM
Citation
 Tumey, LN; Bom, D; Huck, B; Gleason, E; Wang, J; Silver, D; Brunden, K; Boozer, S; Rundlett, S; Sherf, B; Murphy, S; Dent, T; Leventhal, C; Bailey, A; Harrington, J; Bennani, YL The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett 15:277-81 (2004) [PubMed]  Article 
Target
Name:
DNA excision repair protein ERCC-5
Synonyms:
ERCC5 | ERCC5_HUMAN | ERCM2 | XPG | XPGC
Type:
PROTEIN
Mol. Mass.:
133069.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305129
Residue:
1186
Sequence:
MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDRHGNSIENPHLLTLFHRLCKLLFFRIRPIFVFDGDAPLLKKQTLVKRRQRKDLASSDSRKTTEKLLKTFLKRQAIKTAFRSKRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQERMNQKQALQEEFFHNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESDDFSQYQLKGLLKKNYLNQHIEHVQKEMNQQHSGHIRRQYEDEGGFLKEVESRRVVSEDTSHYILIKGIQAKTVAEVDSESLPSSSKMHGMSFDVKSSPCEKLKTEKEPDATPPSPRTLLAMQAALLGSSSEEELESENRRQARGRNAPAAVDEGSISPRTLSAIKRALDDDEDVKVCAGDDVQTGGPGAEEMRINSSTENSDEGLKVRDGKGIPFTATLASSSVNSAEEHVASTNEGREPTDSVPKEQMSLVHVGTEAFPISDESMIKDRKDRLPLESAVVRHSDAPGLPNGRELTPASPTCTNSVSKNETHAEVLEQQNELCPYESKFDSSLLSSDDETKCKPNSASEVIGPVSLQETSSIVSVPSEAVDNVENVVSFNAKEHENFLETIQEQQTTESAGQDLISIPKAVEPMEIDSEESESDGSFIEVQSVISDEELQAEFPETSKPPSEQGEEELVGTREGEAPAESESLLRDNSERDDVDGEPQEAEKDAEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFLESQELLRLFGIPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRNFFNKNKFVEYYQYVDFHNQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGHGLEPLLKFSEWWHEAQKNPKIRPNPHDTKVKKKLRTLQLTPGFPNPAVAEAYLKPVVDDSKGSFLWGKPDLDKIREFCQRYFGWNRTKTDESLFPVLKQLDAQQTQLRIDSFFRLAQQEKEDAKRIKSQRLNRAVTCMLRKEKEAAASEIEAVSVAMEKEFELLDKAKGKTQKRGITNTLEESSSLKRKRLSDSKGKNTCGGFLGETCLSESSDGSSSEDAESSSLMNVQRRTAAKEPKTSASDSQNSVKEAPVKNGGATTSSSSDSDDDGGKEKMVLVTARSVFGKKRRKLRRARGRKRKT
  
Inhibitor
Name:
BDBM50157845
Synonyms:
7-(4-Bromo-phenyl)-3-hydroxy-1H-furo[3,2-d]pyrimidine-2,4-dione | CHEMBL180566
Type:
Small organic molecule
Emp. Form.:
C12H7BrN2O4
Mol. Mass.:
323.099
SMILES:
On1c(=O)[nH]c2c(coc2c1=O)-c1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: