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Found 4291 with Last Name = 'huck' and Initial = 'b'
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188136((3aS,8R,8aS)-6,7-dichloro-8-methyl-1,2,3,3a,8,8a-h...)
Affinity DataKi:  5nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188139((3aS,8R,8aS)-6-chloro-5-methoxy-8-methyl-1,2,3,3a,...)
Affinity DataKi:  14nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188140((3aS,8R,8aS)-6-chloro-8-methyl-1,2,3,3a,8,8a-hexah...)
Affinity DataKi:  27nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188144((3aS,8R,8aS)-6-bromo-5-methoxy-8-methyl-1,2,3,3a,8...)
Affinity DataKi:  27nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188143((+/-)-(3aS,8aS)-5,6-dichloro-8-methyl-1,2,3,3a,8,8...)
Affinity DataKi:  103nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188134((+/-)-(3aS,8aS)-6-chloro-5,8-dimethyl-1,2,3,3a,8,8...)
Affinity DataKi:  107nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188127((3aS,8R,8aS)-5-chloro-6,8-dimethyl-1,2,3,3a,8,8a-h...)
Affinity DataKi:  134nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188137((3aS,8R,8aS)-6-chloro-5,8-dimethyl-1,2,3,3a,8,8a-h...)
Affinity DataKi:  155nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188129((3aS,8R,8aS)-5,6-dichloro-8-methyl-1,2,3,3a,8,8a-h...)
Affinity DataKi:  155nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188142((+/-)-(3aS,8aS)-5-bromo-6,8-dimethyl-1,2,3,3a,8,8a...)
Affinity DataKi:  207nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188146((3aS,8R,8aS)-6-chloro-5-ethoxy-8-methyl-1,2,3,3a,8...)
Affinity DataKi:  231nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188130((+/-)-(3aS,8aS)-6-bromo-5,8-dimethyl-1,2,3,3a,8,8a...)
Affinity DataKi:  463nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188128((+/-)-(3aS,8aS)-5-chloro-6,8-dimethyl-1,2,3,3a,8,8...)
Affinity DataKi:  465nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291573(N-(3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)a...)
Affinity DataKi:  530nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188135((+/-)-(3aS,8aS)-6-chloro-5-methoxy-8-methyl-1,2,3,...)
Affinity DataKi:  530nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291413(1-(6-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)a...)
Affinity DataKi:  780nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188125((3aS,8R,8aS)-6-chloro-8-methyl-1,2,3,3a,8,8a-hexah...)
Affinity DataKi:  911nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188132((3aS,8S,8aS)-5,6-dichloro-8-methyl-1,2,3,3a,8,8a-h...)
Affinity DataKi:  1.14E+3nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291455(N-(4-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)a...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188147((+/-)-(3aS,8aS)-6,8-dimethyl-1,2,3,3a,8,8a-hexahyd...)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291452(N-((1R,3S)-3-((6-amino-5-(4-phenoxyphenyl)pyrimidi...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188141((+/-)-(3aS,8aS)-4,8-dimethyl-1,2,3,3a,8,8a-hexahyd...)
Affinity DataKi:  1.85E+3nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188131((+/-)-(3aS,8aS)-5-fluoro-8-methyl-1,2,3,3a,8,8a-he...)
Affinity DataKi:  3.01E+3nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291522(1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)...)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188138((+/-)-(3aS,8aS)-5,8-dimethyl-1,2,3,3a,8,8a-hexahyd...)
Affinity DataKi:  3.31E+3nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188133((+/-)-(3aS,8aS)-7,8-dimethyl-1,2,3,3a,8,8a-hexahyd...)
Affinity DataKi:  3.38E+3nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50188145((+/-)-(3aS,8aS)-6-fluoro-8-methyl-1,2,3,3a,8,8a-he...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157851(3''-(3-Hydroxy-2,4-dioxo-3,4-dihydro-2H-thieno[3,2...)
Affinity DataIC50:  0.00300nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157833(CHEMBL182077 | N-[3''-(3-Hydroxy-2,4-dioxo-3,4-dih...)
Affinity DataIC50:  0.00400nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157854(5,6-Dibutyl-3-hydroxy-1H-thieno[2,3-d]pyrimidine-2...)
Affinity DataIC50:  0.00900nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM116986(US8637532, 713)
Affinity DataIC50:  0.0100nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157843(7-Benzenesulfonyl-3-hydroxy-1H-thieno[3,2-d]pyrimi...)
Affinity DataIC50:  0.0100nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157840(1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-...)
Affinity DataIC50:  0.0110nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157830(3-Hydroxy-7-phenyl-1H-thieno[3,2-d]pyrimidine-2,4-...)
Affinity DataIC50:  0.0120nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157842(3-Hydroxy-5-methyl-4a,7a-dihydro-1H-thieno[2,3-d]p...)
Affinity DataIC50:  0.0140nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157853(5-Chloro-3-hydroxy-4a,8a-dihydro-1H-quinazoline-2,...)
Affinity DataIC50:  0.0140nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157828(3-Hydroxy-1-(7-methoxy-benzo[1,3]dioxol-5-ylmethyl...)
Affinity DataIC50:  0.0180nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA excision repair protein ERCC-5(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157843(7-Benzenesulfonyl-3-hydroxy-1H-thieno[3,2-d]pyrimi...)
Affinity DataIC50:  0.0230nMAssay Description:Inhibitory concentration against the xeroderma pigmentosum GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157841(7-Biphenyl-4-yl-3-hydroxy-1H-furo[3,2-d]pyrimidine...)
Affinity DataIC50:  0.0230nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157832(3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...)
Affinity DataIC50:  0.0250nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA excision repair protein ERCC-5(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157830(3-Hydroxy-7-phenyl-1H-thieno[3,2-d]pyrimidine-2,4-...)
Affinity DataIC50:  0.0280nMAssay Description:Inhibitory concentration against the xeroderma pigmentosum GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157844(3-Hydroxy-5-methyl-1-phenyl-1H-thieno[2,3-d]pyrimi...)
Affinity DataIC50:  0.0280nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM116550(US8637532, 241)
Affinity DataIC50:  0.0300nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM116576(US8637532, 268)
Affinity DataIC50:  0.0300nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157837(3-Hydroxy-7-(3-methoxy-phenyl)-1H-furo[3,2-d]pyrim...)
Affinity DataIC50:  0.0310nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157838(3-Hydroxy-7-(4-methoxy-phenyl)-1H-furo[3,2-d]pyrim...)
Affinity DataIC50:  0.0340nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157839(3-Hydroxy-1-(4-methoxy-phenyl)-5-methyl-1H-thieno[...)
Affinity DataIC50:  0.0350nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157836(7-Benzyl-3-hydroxy-1H-furo[3,2-d]pyrimidine-2,4-di...)
Affinity DataIC50:  0.0380nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM116811(US8637532, 537)
Affinity DataIC50:  0.0400nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM116714(US8637532, 423)
Affinity DataIC50:  0.0420nMAssay Description:The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...More data for this Ligand-Target Pair
In DepthDetails US Patent
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