Reaction Details
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Cholesterol side-chain cleavage enzyme, mitochondrial
Ligand
BDBM50600670
Substrate
n/a
Meas. Tech.
ChEMBL_2234669 (CHEMBL5148441)
IC50
3000±n/a nM
Citation
Wu, T; Salim, AA; Khalil, ZG; Bernhardt, PV; Capon, RJ Glenthmycins A-M: Macrocyclic Spirotetronate Polyketide Antibacterials from the Australian Pasture Plant-Derived J Nat Prod 85:1641-1657 (2022) [PubMed] More Info.:
Target
Name:
Cholesterol side-chain cleavage enzyme, mitochondrial
Synonyms:
CP11A_RAT | Cyp11a | Cyp11a-1 | Cyp11a1 | Cytochrome P450 11A1
Type:
PROTEIN
Mol. Mass.:
60603.33
Organism:
Rattus norvegicus
Description:
ChEMBL_50353
Residue:
526
Sequence:
MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYLVPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV
Inhibitor
Name:
BDBM50600670
Synonyms:
CHEMBL5204687
Type:
Small organic molecule
Emp. Form.:
C35H46O6
Mol. Mass.:
562.7361
SMILES:
[H][C@@]12C=C(C)[C@H](C)C[C@]11OC(=O)C(=C1O)C(=O)[C@]1(C)[C@@]([H])(C(C)=C[C@]3([H])[C@H](CC[C@H](C)[C@@]13[H])OC(C)=O)\C(C)=C\CC\C(C)=C\2 |r,c:13,24,t:2,42,47|
Structure:
