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Found 67 with Last Name = 'bernhardt' and Initial = 'pv'
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse BMDM assessed as reduction in NLRP3 inflammasome-induced IL-1beta production prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50058809(CHEMBL3329524)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50058806(CHEMBL3329519)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  67nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  110nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50199870(CHEMBL3904593)
Affinity DataIC50:  232nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-stimulated human monocyte derived macrophages assessed as reduction in NLRP3 inflammasome-induced IL-1beta pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50058805(CHEMBL3329518)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50537903(CHEMBL4639635)
Affinity DataIC50:  350nMAssay Description:Reversal of P-gp mediated multidrug resistance in human SW620/AD300 cells assessed as potentiation of doxorubicin-induced antiproliferative activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50058808(CHEMBL3329521)
Affinity DataIC50:  400nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50058804(CHEMBL3329515)
Affinity DataIC50:  400nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50600678(CHEMBL5176174)
Affinity DataIC50:  500nMAssay Description:Antibacterial activity against Enterococcus faecalis incubated for 16 to 24 hrs by broth microdilution based spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataIC50:  710nMAssay Description:Inhibition of P-gp mediated doxorubicin resistance in human SW620/AD300 cells overexpressing P-gp in presence of doxorubicin measured after 52 hrs by...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataIC50:  810nMAssay Description:Reversal of P-gp mediated multidrug resistance in human SW620/AD300 cells assessed as potentiation of doxorubicin-induced antiproliferative activity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50537908(CHEMBL4641108)
Affinity DataIC50:  820nMAssay Description:Reversal of P-gp mediated multidrug resistance in human SW620/AD300 cells assessed as potentiation of doxorubicin-induced antiproliferative activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50537904(CHEMBL4646781)
Affinity DataIC50:  880nMAssay Description:Reversal of P-gp mediated multidrug resistance in human SW620/AD300 cells assessed as potentiation of doxorubicin-induced antiproliferative activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50596547(CHEMBL5193426)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of P-gp mediated doxorubicin resistance in human SW620/AD300 cells overexpressing P-gp in presence of doxorubicin measured after 52 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50277455(CHEMBL4175281)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50277454(CHEMBL4168083)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50277463(CHEMBL4163526)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50277461(CHEMBL4164649)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50277451(CHEMBL4160164)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50277452(CHEMBL4162052)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50537907(CHEMBL4636390)
Affinity DataIC50:  1.10E+3nMAssay Description:Reversal of P-gp mediated multidrug resistance in human SW620/AD300 cells assessed as potentiation of doxorubicin-induced antiproliferative activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50596546(CHEMBL5194241)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of P-gp mediated doxorubicin resistance in human SW620/AD300 cells overexpressing P-gp in presence of doxorubicin measured after 52 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50277462(CHEMBL4171426)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50199858(CHEMBL3956814)
Affinity DataIC50:  1.24E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-stimulated human monocyte derived macrophages assessed as reduction in NLRP3 inflammasome-induced IL-1beta pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50058802(CHEMBL3329513)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50058803(CHEMBL2409542)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50596548(CHEMBL5205284)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of P-gp mediated doxorubicin resistance in human SW620/AD300 cells overexpressing P-gp in presence of doxorubicin measured after 52 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50596549(CHEMBL5175965)
Affinity DataIC50:  1.48E+3nMAssay Description:Inhibition of P-gp mediated doxorubicin resistance in human SW620/AD300 cells overexpressing P-gp in presence of doxorubicin measured after 52 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50596544(CHEMBL5204503)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of P-gp mediated doxorubicin resistance in human SW620/AD300 cells overexpressing P-gp in presence of doxorubicin measured after 52 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50199871(CHEMBL3920126)
Affinity DataIC50:  1.83E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-stimulated human monocyte derived macrophages assessed as reduction in NLRP3 inflammasome-induced IL-1beta pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50199869(CHEMBL3929254)
Affinity DataIC50:  1.97E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-stimulated human monocyte derived macrophages assessed as reduction in NLRP3 inflammasome-induced IL-1beta pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50600667(CHEMBL5180164)
Affinity DataIC50:  2.70E+3nMAssay Description:Antibacterial activity against Enterococcus faecalis incubated for 16 to 24 hrs by broth microdilution based spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50600670(CHEMBL5204687)
Affinity DataIC50:  3.00E+3nMAssay Description:Antibacterial activity against Enterococcus faecalis incubated for 16 to 24 hrs by broth microdilution based spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50600662(CHEMBL5193721)
Affinity DataIC50:  3.10E+3nMAssay Description:Antibacterial activity against Enterococcus faecalis incubated for 16 to 24 hrs by broth microdilution based spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50600671(CHEMBL5175684)
Affinity DataIC50:  3.70E+3nMAssay Description:Antibacterial activity against Enterococcus faecalis incubated for 16 to 24 hrs by broth microdilution based spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50600666(CHEMBL5178722)
Affinity DataIC50:  4.00E+3nMAssay Description:Antibacterial activity against Enterococcus faecalis incubated for 16 to 24 hrs by broth microdilution based spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50596550(CHEMBL5171374)
Affinity DataIC50:  4.49E+3nMAssay Description:Inhibition of P-gp mediated doxorubicin resistance in human SW620/AD300 cells overexpressing P-gp in presence of doxorubicin measured after 52 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50058807(CHEMBL3329520)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50277453(CHEMBL4174866)
Affinity DataIC50:  4.93E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50596551(CHEMBL5171189)
Affinity DataIC50:  5.04E+3nMAssay Description:Inhibition of P-gp mediated doxorubicin resistance in human SW620/AD300 cells overexpressing P-gp in presence of doxorubicin measured after 52 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50600660(CHEMBL5187573)
Affinity DataIC50:  5.70E+3nMAssay Description:Antibacterial activity against Enterococcus faecalis incubated for 16 to 24 hrs by broth microdilution based spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM22984((8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-me...)
Affinity DataIC50:  5.75E+3nMAssay Description:Inhibition of P-gp mediated doxorubicin resistance in human SW620/AD300 cells overexpressing P-gp measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50600664(CHEMBL5185601)
Affinity DataIC50:  6.20E+3nMAssay Description:Antibacterial activity against Enterococcus faecalis incubated for 16 to 24 hrs by broth microdilution based spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50199868(CHEMBL3906283)
Affinity DataIC50:  6.35E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-stimulated human monocyte derived macrophages assessed as reduction in NLRP3 inflammasome-induced IL-1beta pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50600661(CHEMBL5180114)
Affinity DataIC50:  7.30E+3nMAssay Description:Antibacterial activity against Enterococcus faecalis incubated for 16 to 24 hrs by broth microdilution based spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50596545(CHEMBL5170888)
Affinity DataIC50:  7.58E+3nMAssay Description:Inhibition of P-gp mediated doxorubicin resistance in human SW620/AD300 cells overexpressing P-gp in presence of doxorubicin measured after 52 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50600665(CHEMBL5192274)
Affinity DataIC50:  8.90E+3nMAssay Description:Antibacterial activity against Enterococcus faecalis incubated for 16 to 24 hrs by broth microdilution based spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50058801(CHEMBL3329506)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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