Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50603182
Substrate
n/a
Meas. Tech.
ChEMBL_2243276 (CHEMBL5157486)
IC50
1780±n/a nM
Citation
 Mehndiratta, S; Qian, B; Chuang, JY; Liou, JP; Shih, JC -Methylpropargylamine-Conjugated Hydroxamic Acids as Dual Inhibitors of Monoamine Oxidase A and Histone Deacetylase for Glioma Treatment. J Med Chem 65:2208-2224 (2022) [PubMed] 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50603182
Synonyms:
CHEMBL5177240
Type:
Small organic molecule
Emp. Form.:
C21H29Cl2N3O4
Mol. Mass.:
458.379
SMILES:
CN(CCCOc1cc(NC(=O)CCCCCCC(=O)NO)c(Cl)cc1Cl)CC#C
Structure:
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