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Target
RNA-directed RNA polymerase
Ligand
BDBM50187136
Substrate
n/a
Meas. Tech.
ChEMBL_386030 (CHEMBL870300)
IC50
77300±n/a nM
Citation
 Ontoria, JM; Martìn Hernando, JI; Malancona, S; Attenni, B; Stansfield, I; Conte, I; Ercolani, C; Habermann, J; Ponzi, S; Di Filippo, M; Koch, U; Rowley, M; Narjes, F Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase. Bioorg Med Chem Lett 16:4026-30 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50187136
Synonyms:
3-(1-cyclohexyl-2-(4-methoxyphenyl)-1H-imidazol-4-yl)acrylic acid | CHEMBL214165
Type:
Small organic molecule
Emp. Form.:
C19H22N2O3
Mol. Mass.:
326.3896
SMILES:
COc1ccc(cc1)-c1nc(\C=C\C(O)=O)cn1C1CCCCC1
Structure:
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