Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50187143
Substrate
n/a
Meas. Tech.
ChEMBL_386030 (CHEMBL870300)
IC50
>50000±n/a nM
Citation
 Ontoria, JM; Martìn Hernando, JI; Malancona, S; Attenni, B; Stansfield, I; Conte, I; Ercolani, C; Habermann, J; Ponzi, S; Di Filippo, M; Koch, U; Rowley, M; Narjes, F Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase. Bioorg Med Chem Lett 16:4026-30 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50187143
Synonyms:
3-cyclohexyl-2-phenylquinoline-7-carboxylic acid | CHEMBL211712
Type:
Small organic molecule
Emp. Form.:
C22H21NO2
Mol. Mass.:
331.4076
SMILES:
OC(=O)c1ccc2cc(C3CCCCC3)c(nc2c1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: