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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM50606278
Substrate
n/a
Meas. Tech.
ChEMBL_2254285 (CHEMBL5168495)
EC50
2600±n/a nM
Citation
 Griffith, DA; Edmonds, DJ; Fortin, JP; Kalgutkar, AS; Kuzmiski, JB; Loria, PM; Saxena, AR; Bagley, SW; Buckeridge, C; Curto, JM; Derksen, DR; Dias, JM; Griffor, MC; Han, S; Jackson, VM; Landis, MS; Lettiere, D; Limberakis, C; Liu, Y; Mathiowetz, AM; Patel, JC; Piotrowski, DW; Price, DA; Ruggeri, RB; Tess, DA A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor. J Med Chem 65:8208-8226 (2022) [PubMed] 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM50606278
Synonyms:
CHEMBL5209130
Type:
Small organic molecule
Emp. Form.:
C25H25ClFN5O
Mol. Mass.:
465.95
SMILES:
Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccncc12
Structure:
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