Reaction Details Report a problem with these data
Target
Cholinesterase
Ligand
BDBM50022775
Substrate
n/a
Meas. Tech.
ChEMBL_2280306
IC50
160±n/a nM
Citation
Aranha, CMSQ; Reiner-Link, D; Leitzbach, LR; Lopes, FB; Stark, H; Fernandes, JPS Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H Bioorg Med Chem 78:0 (2023) [PubMed]
More Info.:
Target
Name:
Cholinesterase
Synonyms:
BCHE | Butyrylcholinesterase (BuChE) | CHLE_HORSE | Cholinesterase
Type:
Enzyme
Mol. Mass.:
65643.35
Organism:
Horse
Description:
P81908
Residue:
574
Sequence:
EEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATKYANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQKNIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEARNRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLTDMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPRVSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTRKFSELGNDAFFYYFEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEILSRSIMKRWANFAKYGNPNGTQNNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAEREWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
Inhibitor
Name:
BDBM50022775
Synonyms:
(m-Hydroxyphenyl)trimethylammonium dimethylcarbamate | 3-Trimethylammoniumphenyl N,N-dimethylcarbamate | 3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium | CHEMBL211471 | CHEMBL278020 | Eustigmin | Eustigmine | NEOSTIGMINE | Neostigmine (2) | Prostigmine | Vagostigmine | m-Trimethylammoniumphenyldimethylcarbamate
Type:
Small organic molecule
Emp. Form.:
C12H19N2O2
Mol. Mass.:
223.2909
SMILES:
CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C