Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50220693
Substrate
n/a
Meas. Tech.
ChEMBL_457383 (CHEMBL941902)
IC50
6.8±n/a nM
Citation
Sebhat, IK; Lai, Y; Barakat, K; Ye, Z; Tang, R; Kalyani, RN; Vongs, A; Macneil, T; Weinberg, DH; Cabello, MA; Maroto, M; Teran, A; Fong, TM; Van der Ploeg, LH; Patchett, AA; Nargund, RP Melanocortin subtype 4 receptor agonists: structure-activity relationships about the 4-alkyl piperidine core. Bioorg Med Chem Lett 17:5720-3 (2007) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Human
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Inhibitor
Name:
BDBM50220693
Synonyms:
(R)-N-((S)-3-(4-chlorophenyl)-1-(4-(cyanomethyl)-4-cyclohexylpiperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | CHEMBL251735
Type:
Small organic molecule
Emp. Form.:
C32H39ClN4O2
Mol. Mass.:
547.131
SMILES:
Clc1ccc(C[C@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(CC#N)(CC2)C2CCCCC2)cc1