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Target
Prostasin
Ligand
BDBM50247003
Substrate
n/a
Meas. Tech.
ChEMBL_557785 (CHEMBL953294)
Ki
176±n/a nM
Citation
 Tully, DC; Vidal, A; Chatterjee, AK; Williams, JA; Roberts, MJ; Petrassi, HM; Spraggon, G; Bursulaya, B; Pacoma, R; Shipway, A; Schumacher, AM; Danahay, H; Harris, JL Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Bioorg Med Chem Lett 18:5895-9 (2008) [PubMed]  Article 
Target
Name:
Prostasin
Synonyms:
PRSS8 | PRSS8_HUMAN
Type:
PROTEIN
Mol. Mass.:
36426.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_557785
Residue:
343
Sequence:
MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQTQESQPDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH
  
Inhibitor
Name:
BDBM50247003
Synonyms:
CHEMBL501945 | {(R)-1-[(2S,4R)-2-[(S)-5-Amino-1-(benzooxazole-2-carbonyl)-pentylcarbamoyl]-4-(4-methanesulfonyl-benzylcarbamoyloxy)-pyrrolidine-1-carbonyl]-3-phenyl-propyl}-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C45H50N6O10S
Mol. Mass.:
866.978
SMILES:
CS(=O)(=O)c1ccc(CNC(=O)O[C@@H]2C[C@H](N(C2)C(=O)[C@@H](CCc2ccccc2)NC(=O)OCc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)c2nc3ccccc3o2)cc1 |r|
Structure:
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