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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM50263356
Substrate
n/a
Meas. Tech.
ChEMBL_535435 (CHEMBL985261)
IC50
41±n/a nM
Citation
 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Pharmacophore modeling and virtual screening for designing potential PLK1 inhibitors. Bioorg Med Chem Lett 18:4972-7 (2008) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM50263356
Synonyms:
5-((2-(1-cyano-2-oxo-2-(2,2,2-trifluoroethylamino)ethylidene)-3-ethyl-4-oxothiazolidin-5-ylidene)methylamino)-N-(2-(diethylamino)ethyl)-1H-indole-3-carboxamide | CHEMBL475881
Type:
Small organic molecule
Emp. Form.:
C26H30F3N7O3S
Mol. Mass.:
577.622
SMILES:
CCN(CC)CCNC(=O)c1c[nH]c2ccc(N\C=c3\s\c(=C(\C#N)C(=O)NCC(F)(F)F)n(CC)c3=O)cc12
Structure:
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