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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50277145
Substrate
n/a
Meas. Tech.
ChEMBL_540736 (CHEMBL1030618)
Ki
5.2±n/a nM
Citation
 Dounay, AB; Barta, NS; Bikker, JA; Borosky, SA; Campbell, BM; Crawford, T; Denny, L; Evans, LM; Gray, DL; Lee, P; Lenoir, EA; Xu, W Synthesis and pharmacological evaluation of aminopyrimidine series of 5-HT1A partial agonists. Bioorg Med Chem Lett 19:1159-63 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50277145
Synonyms:
(+/-)-4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-tert-butylpyrimidin-2-amine | CHEMBL475516
Type:
Small organic molecule
Emp. Form.:
C23H31N5
Mol. Mass.:
377.5257
SMILES:
CC(C)(C)Nc1nccc(n1)C1CCCN(CCc2c[nH]c3ccccc23)C1
Structure:
Search PDB for entries with ligand similarity: