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Target
Thromboxane A2 receptor
Ligand
BDBM50259611
Substrate
n/a
Meas. Tech.
ChEMBL_500484 (CHEMBL1009661)
Ki
10±n/a nM
Citation
 Hall, A; Billinton, A; Brown, SH; Chowdhury, A; Clayton, NM; Giblin, GM; Gibson, M; Goldsmith, PA; Hurst, DN; Naylor, A; Peet, CF; Scoccitti, T; Wilson, AW; Winchester, W Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP(1) receptor antagonist for the treatment of inflammatory pain. Bioorg Med Chem Lett 19:2599-603 (2009) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50259611
Synonyms:
CHEMBL467114 | sodium 6-(5-chloro-2-(4-chloro-2-fluorobenzyloxy)benzyl)picolinate
Type:
Small organic molecule
Emp. Form.:
C20H13Cl2FNO3
Mol. Mass.:
405.227
SMILES:
[O-]C(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Structure:
Search PDB for entries with ligand similarity: