Reaction Details Report a problem with these data
Target
Sterol O-acyltransferase 1
Ligand
BDBM50287513
Substrate
n/a
Meas. Tech.
ChEMBL_28510 (CHEMBL642849)
IC50
35±n/a nM
Citation
 Purchase, CF; White, AD; Anderson, MK; Bocan, TM; Bousley, RF; Hamelehle, KL; Homan, R; Krause, BR; Lee, P; Mueller, SB; Speyer, C; Stanfield, RL; Reindel, JF Tetrazole-substituted ureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). A novel preparation of ureas from weakly nucleophilic amines Bioorg Med Chem Lett 6:1753-1758 (1996)    Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50287513
Synonyms:
1-Benzyl-1-(2-dodecyl-2H-tetrazol-5-yl)-3-(2,4,6-trimethoxy-phenyl)-urea | CHEMBL49223
Type:
Small organic molecule
Emp. Form.:
C30H44N6O4
Mol. Mass.:
552.7082
SMILES:
CCCCCCCCCCCCn1nnc(n1)N(Cc1ccccc1)C(=O)Nc1c(OC)cc(OC)cc1OC
Structure:
Search PDB for entries with ligand similarity: