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Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50414549
Substrate
n/a
Meas. Tech.
ChEMBL_581546 (CHEMBL1060745)
Ki
6.31±n/a nM
Citation
 Hilfiker, MA; Wang, N; Hou, X; Du, Z; Pullen, MA; Nord, M; Nagilla, R; Fries, HE; Wu, CW; Sulpizio, AC; Jaworski, JP; Morrow, D; Edwards, RM; Jin, J Discovery of novel aminothiadiazole amides as selective EP(3) receptor antagonists. Bioorg Med Chem Lett 19:4292-5 (2009) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_RAT | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor EP3 subtype | Prostanoid EP3 receptor | Ptger3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39958.37
Organism:
Rat
Description:
Prostaglandin E2 PTGER2 RAT::P34980
Residue:
365
Sequence:
MAGVWAPEHSVEAHSNQSSAADGCGSVSVAFPITMMVTGFVGNALAMLLVVRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDSAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSVLMWSDQLER
  
Inhibitor
Name:
BDBM50414549
Synonyms:
CHEMBL563480
Type:
Small organic molecule
Emp. Form.:
C19H16Cl2N4O2S
Mol. Mass.:
435.327
SMILES:
CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)-c1c(Cl)cccc1Cl
Structure:
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