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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50305730
Substrate
n/a
Meas. Tech.
ChEMBL_604746 (CHEMBL1071905)
IC50
85±n/a nM
Citation
 Jerome, KD; Rucker, PV; Xing, L; Shieh, HS; Baldus, JE; Selness, SR; Letavic, MA; Braganza, JF; McClure, KF Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition. Bioorg Med Chem Lett 20:469-73 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50305730
Synonyms:
6-(2,4-difluorophenethyl)-3-isopropyl-1,8a-dihydro-[1,2,4]triazolo[4,3-a]pyridine | CHEMBL610487
Type:
Small organic molecule
Emp. Form.:
C17H19F2N3
Mol. Mass.:
303.3497
SMILES:
CC(C)c1nnc2CCC(CCc3ccc(F)cc3F)=Cn12 |c:20|
Structure:
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