Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM50311983
Substrate
n/a
Meas. Tech.
ChEMBL_620206 (CHEMBL1115841)
IC50
1±n/a nM
Citation
 Wang, XBerger, DMSalaski, EJTorres, NHu, YLevin, JIPowell, DWojciechowicz, DCollins, KFrommer, E Discovery of highly potent and selective type I B-Raf kinase inhibitors. Bioorg Med Chem Lett 19:6571-4 (2009) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM50311983
Synonyms:
(R)-3-(2-(pyridin-4-yl)-7-(4-(quinuclidin-3-ylamino)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol | CHEMBL1086871
Type:
Small organic molecule
Emp. Form.:
C30H28N6O
Mol. Mass.:
488.5829
SMILES:
Oc1cccc(c1)-c1c(nn2c(ccnc12)-c1ccc(N[C@H]2CN3CCC2CC3)cc1)-c1ccncc1 |r,wU:21.23,(27.09,-49.36,;27.87,-48.04,;29.41,-48.05,;30.19,-46.72,;29.43,-45.38,;27.9,-45.37,;27.11,-46.7,;27.16,-44.03,;28.07,-42.79,;27.17,-41.54,;25.71,-42,;24.37,-41.24,;23.04,-42,;23.03,-43.54,;24.36,-44.31,;25.7,-43.54,;24.37,-39.7,;23.04,-38.93,;23.05,-37.39,;24.37,-36.62,;24.39,-35.08,;25.74,-34.33,;25.77,-32.78,;27.12,-32.02,;28.45,-32.82,;28.42,-34.36,;27.07,-35.12,;27.58,-33.8,;26.3,-33.23,;25.71,-37.38,;25.72,-38.93,;29.61,-42.8,;30.37,-44.14,;31.91,-44.15,;32.69,-42.82,;31.92,-41.48,;30.38,-41.47,)|
Structure:
Search PDB for entries with ligand similarity: