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Found 1831 with Last Name = 'powell' and Initial = 'd'
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463046(CHEMBL1229989)
Affinity DataKi:  15nMAssay Description:Inhibition of human glycolate oxidase expressed in Escherichia coli using glycolate as substrate by DCIP dye based spectrophotometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50325178((R)-3-amino-N-(2-chloro-5-(3-methoxypropyl)benzyl)...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataKi:  4.50E+3nMAssay Description:Non competitive inhibition of mouse glycolate oxidase in hyperoxaluric-Agxt knockdown mouse primary hepatocyte assessed as reduction in oxalate produ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28123(3-cyanoquinoline, 8 | 4-({3-chloro-4-[(1-methyl-1H...)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of MEK1 phosphorylation in LoVo cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572932(CHEMBL4850573)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50314654(3-amino-N-(2-chloro-5-(3-hydroxypropyl)benzyl)-N-c...)
Affinity DataIC50:  0.0900nMpH: 7.4Assay Description:Inhibition of human recombinant renin in PBS buffer at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50325178((R)-3-amino-N-(2-chloro-5-(3-methoxypropyl)benzyl)...)
Affinity DataIC50:  0.0900nMpH: 7.4Assay Description:Inhibition of human recombinant renin in presence of pH 7.4 bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50314646((S)-3-amino-N-(2-chloro-5-(3-methoxypropyl)benzyl)...)
Affinity DataIC50:  0.0900nMpH: 7.4Assay Description:Inhibition of human recombinant renin in PBS buffer at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572931(CHEMBL4855986)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026207(CHEMBL1276170)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026212(CHEMBL1276185)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Mus musculus (Mouse))
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50250656(CHEMBL4081890 | US11247971, Cmpd ID 276)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50330925(7-(2,6-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyc...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50314653((S)-3-amino-N-(2-chloro-5-(3-cyanopropyl)benzyl)-N...)
Affinity DataIC50:  0.110nMpH: 7.4Assay Description:Inhibition of human recombinant renin in PBS buffer at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM6469(4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonit...)
Affinity DataIC50:  0.150nMpH: 7.5 T: 2°CAssay Description:Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50330905(7-(2,6-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyc...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50314655(3-amino-N-((5-chloro-2-(3-methoxypropyl)pyridin-4-...)
Affinity DataIC50:  0.190nMpH: 7.4Assay Description:Inhibition of human recombinant renin in PBS buffer at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50314648(3-amino-N-(2-chloro-5-(2-methoxyethyl)benzyl)-N-cy...)
Affinity DataIC50:  0.190nMpH: 7.4Assay Description:Inhibition of human recombinant renin in PBS buffer at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Mus musculus (Mouse))
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572933(CHEMBL4861379)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Mus musculus (Mouse))
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572931(CHEMBL4855986)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50314647(3-amino-N-(2-chloro-5-(2-methoxyethoxy)benzyl)-N-c...)
Affinity DataIC50:  0.210nMpH: 7.4Assay Description:Inhibition of human recombinant renin in PBS buffer at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM6479(4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonit...)
Affinity DataIC50:  0.220nMpH: 7.5 T: 2°CAssay Description:Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50330924(7-(2-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50314651(3-amino-N-cyclopropyl-2-(4-(3-(2,6-dichloro-4-meth...)
Affinity DataIC50:  0.260nMpH: 7.4Assay Description:Inhibition of human recombinant renin in PBS buffer at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50314645((+/-)-3-amino-N-(2-chloro-5-(3-methoxypropyl)benzy...)
Affinity DataIC50:  0.260nMpH: 7.4Assay Description:Inhibition of human recombinant renin in PBS buffer at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50314652(3-amino-N-(2-chloro-5-(2-cyanoethyl)benzyl)-N-cycl...)
Affinity DataIC50:  0.270nMpH: 7.4Assay Description:Inhibition of human recombinant renin in PBS buffer at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM6472(4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonit...)
Affinity DataIC50:  0.290nMpH: 7.5 T: 2°CAssay Description:Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572934(CHEMBL4847068)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50314656(4-((3-amino-N-cyclopropyl-2-(4-(3-(2,6-dichloro-4-...)
Affinity DataIC50:  0.300nMpH: 7.4Assay Description:Inhibition of human recombinant renin in PBS buffer at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572933(CHEMBL4861379)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303103(1-(3-(3-(4-chloro-3-hydroxyphenyl)-2-(pyridin-4-yl...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Mus musculus (Mouse))
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572930(CHEMBL4873879)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM6470(4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonit...)
Affinity DataIC50:  0.310nMpH: 7.5 T: 2°CAssay Description:Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50025947(CHEMBL1088438)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50025938(CHEMBL1088439)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026023(CHEMBL1080931)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026022(CHEMBL1081283)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026210(CHEMBL1276196)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026206(CHEMBL1276195)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026211(CHEMBL1276184)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026205(CHEMBL1276194)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026209(CHEMBL1276171)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026208(CHEMBL1276193)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026028(CHEMBL1087001)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026030(CHEMBL1080833)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026010(CHEMBL1087013)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026014(CHEMBL1081284)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026013(CHEMBL1086882)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50025981(CHEMBL1088437)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM6474(4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonit...)
Affinity DataIC50:  0.330nMpH: 7.5 T: 2°CAssay Description:Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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