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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM50319677
Substrate
n/a
Meas. Tech.
ChEMBL_634700 (CHEMBL1118785)
IC50
5800±n/a nM
Citation
 Ghiron, C; Haydar, SN; Aschmies, S; Bothmann, H; Castaldo, C; Cocconcelli, G; Comery, TA; Di, L; Dunlop, J; Lock, T; Kramer, A; Kowal, D; Jow, F; Grauer, S; Harrison, B; La Rosa, S; Maccari, L; Marquis, KL; Micco, I; Nencini, A; Quinn, J; Robichaud, AJ; Roncarati, R; Scali, C; Terstappen, GC; Turlizzi, E; Valacchi, M; Varrone, M; Zanaletti, R; Zanelli, U Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914). J Med Chem 53:4379-89 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM50319677
Synonyms:
1-(4'-fluorobiphenyl-4-yl)-3-(4-(piperidin-1-yl)butyl)urea | CHEMBL1084631
Type:
Small organic molecule
Emp. Form.:
C22H28FN3O
Mol. Mass.:
369.4756
SMILES:
Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: