Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50329137
Substrate
n/a
Meas. Tech.
ChEMBL_674397 (CHEMBL1274726)
Ki
0.8±n/a nM
Citation
 Tong, L; Shankar, BB; Chen, L; Rizvi, R; Kelly, J; Gilbert, E; Huang, C; Yang, DY; Kozlowski, JA; Shih, NY; Gonsiorek, W; Hipkin, RW; Malikzay, A; Lunn, CA; Lundell, DJ Expansion of SAR studies on triaryl bis sulfone cannabinoid CB2 receptor ligands. Bioorg Med Chem Lett 20:6785-9 (2010) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50329137
Synonyms:
1,1,1-trifluoro-N-((1-(1-(2-fluorophenylsulfonyl)-5-methoxy-1H-indol-2-ylsulfonyl)piperidin-4-yl)methyl)methanesulfonamide | CHEMBL1270579
Type:
Small organic molecule
Emp. Form.:
C22H23F4N3O7S3
Mol. Mass.:
613.623
SMILES:
COc1ccc2n(c(cc2c1)S(=O)(=O)N1CCC(CNS(=O)(=O)C(F)(F)F)CC1)S(=O)(=O)c1ccccc1F
Structure:
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