Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50291167
Substrate
n/a
Meas. Tech.
ChEBML_212354
IC50
4.2±n/a nM
Citation
 Akiyama, Y; Tsutsumi, S; Hatsushiba, E; Ohuchi, S; Okonogi, T Peptidyl -keto thiazole as potent thrombin inhibitors Bioorg Med Chem Lett 7:533-538 (1997)    Article 
Target
Name:
Serine protease 1
Synonyms:
Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bos taurus (bovine)
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
  
Inhibitor
Name:
BDBM50291167
Synonyms:
1-((S)-Oxo-3-(R)-2-amino-1-phenyl-propyl)-pyrrolidine-2-carboxylic acid [(S)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-amide | CHEMBL150338
Type:
Small organic molecule
Emp. Form.:
C23H31N7O3S
Mol. Mass.:
485.602
SMILES:
N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nccs1
Structure:
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